It depends on why you fast. A 5-tablet serving of Perfect Aminos has only a few calories, so it barely matters for weight loss. The essential amino acids, leucine in particular, switch on the muscle-building signal mTOR, which works against autophagy and a strict protein-free fast.
| Calories | ~2-4 kcal per 5 tablets |
|---|---|
| Breaks a weight-loss fast? | No |
| Breaks ketosis? | No |
| Breaks autophagy? | Yes |
| Insulin impact | Small rise possible |
Free amino acids are counted as close to calorie-free by the brand because the body uses most of them to build protein. Their effect is hormonal more than caloric: leucine signals the body that protein has arrived, which turns on muscle synthesis and turns down autophagy.
People fasting for weight loss or around early training sometimes take amino acids to protect muscle. Studies on fasted training with amino acids are small and mixed. If your aim is the cellular clean-up linked to longer fasts, amino acids defeat the purpose.
For weight-loss fasting, a serving before a fasted workout is unlikely to matter. For an autophagy or water fast, skip them until your eating window.
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